When used in combination with oral hypoglycaemics, Levemir should be initiated at  10iu or 0.1–0.2iu/kg once daily and titrated according to individual patient requirements. When initiating therapy with Levemir, concomitant antidiabetic treatment may need to be adjusted, including the dose and/or timing of oral hypoglycaemics or concurrent short- or rapid-acting insulins.

According to the product labelling, in three clinical studies, a higher frequency of allergic reactions, and potential allergic reactions, was observed in patients treated with Levemir in combination with oral hypoglycaemic agents.

Further information: Novo Nordisk 0845 6005055